Humans assume different production roles in a workspace. On one hand, humans design workplans to complete tasks as efficiently as possible in order to improve productivity. On the other hand, a nice workspace is essential to facilitate teamwork. In this way, workspace design and workplan design complement each other. Inspired by such observations, we propose an automatic approach to jointly design a workspace and a workplan. Taking staff properties, a space, and work equipment as input, our approach jointly optimizes a workspace and a workplan, considering performance factors such as time efficiency and congestion avoidance, as well as workload factors such as walk effort, turn effort, and workload balances. To enable exploration of design trade-offs, our approach generates a set of Pareto-optimal design solutions with strengths on different objectives, which can be adopted for different work scenarios. We apply our approach to synthesize workspaces and workplans for different workplaces such as a fast food kitchen and a supermarket. We also extend our approach to incorporate other common work considerations such as dynamic work demands and accommodating staff members with different physical capabilities. Evaluation experiments with simulations validate the efficacy of our approach for synthesizing effective workspaces and workplans.